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The genesis of this paper is the proposal that genomes containing a poor percentage of guanosine and cytosine GC nucleotide pairs lead to proteomes more prone to aggregation than those encoded by GC-rich genomes. As a consequence these organisms are also more dependent on the protein folding machinery. If true, this interesting hypothesis could establish a direct link between the tendency to aggregate and the genomic code. In their paper, the authors have tested the hypothesis on the genomes of eubacteria using a genome-wide approach based on multiple machine learning models.

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Comparison of the Young-Laplace law and finite element based calculation of ventricular wall stress: implications for postinfarct and surgical ventricular remodeling. Both the Young-Laplace law and finite element FE based methods have been used to calculate left ventricular wall stress. We tested the hypothesis that the Young-Laplace law is able to reproduce results obtained with the FE method.

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To evaluate the efficacy of serial minimal stimulation IVF cycles with vitrification of embryos for treatment of poor responders as compared to conventional IVF protocols. Accumulating vitrified embryos in serial minimal stimulation cycles ACCU-VIT followed by a frozen embryo transfer is a better treatment option for poor ovarian responders as compared to conventional IVF. Previous trials have shown that neither conventional IVF nor natural cycle IVF is an effective treatment option for poor ovarian responders.

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The genesis of this paper is the proposal that genomes containing a poor percentage of guanosine and cytosine GC nucleotide pairs lead to proteomes more prone to aggregation than those encoded by GC-rich genomes. As a consequence these organisms are also more dependent on the protein folding machinery. If true, this interesting hypothesis could establish a direct link between the tendency to aggregate and the genomic code.

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